Long Island,
New York

Ketamine can produce antidepressant effects more rapidly than conventional antidepressant medications for some people with depression, particularly treatment-resistant depression. Some patients may notice changes within hours or during the first few days after treatment, although response time and degree of improvement vary from person to person.

Ketamine works through pathways involving glutamate signaling, NMDA and AMPA receptors, and mechanisms associated with synaptic plasticity. Learn more about how ketamine works for depression .

The duration of ketamine's antidepressant effects varies by patient. Some people experience improvement that lasts for days or weeks after an individual treatment, while others may require a series of treatments followed by individualized maintenance therapy.

Factors such as the severity and duration of depression, previous treatment response, medical history, medications, and individual response can influence how long benefits persist.

Ketamine treatment for depression is generally administered as a series rather than as a single isolated treatment. The appropriate number and frequency of infusions varies based on diagnosis, symptoms, prior treatment history, response, and the treating clinician's recommendations.

Learn more about ketamine treatment for depression .

Benefits from ketamine treatment can persist beyond the immediate treatment period, but the duration differs substantially between patients. Some people experience sustained improvement after an initial treatment series, while others may benefit from periodic maintenance treatments.

Long-term treatment decisions are typically based on symptom response and ongoing clinical evaluation rather than a fixed treatment schedule.

Ketamine is commonly considered for people with depression who have not experienced adequate improvement from conventional treatments. This is often referred to as treatment-resistant depression, or TRD.

Because ketamine acts through different neurobiological pathways than traditional antidepressants, it may provide another treatment option for appropriately selected patients. Learn more about treatment-resistant depression treatment in New York .

The cost of ketamine treatment depends on the type of treatment and the number of sessions recommended as part of an individual treatment plan. IV ketamine treatment is typically paid directly by the patient, although financing or discount options may sometimes be available.

For current pricing and payment information, visit ketamine treatment fees and insurance .

Coverage depends on the treatment being provided and the patient's insurance benefits. IV ketamine for mental health conditions is often not covered by insurance.

SPRAVATO® (esketamine), by contrast, is an FDA-approved treatment for certain depression indications and may be covered for eligible patients. Learn more about insurance-covered depression treatment in New York .

IV ketamine and SPRAVATO® are related treatments, but they are not the same medication or delivered in the same way. IV ketamine is administered intravenously in a medically supervised setting, while SPRAVATO® contains esketamine and is administered as a nasal spray under medical supervision.

SPRAVATO® is FDA-approved for specific depression indications, while IV ketamine for depression is used off-label based on clinical evidence and physician judgment. The most appropriate option depends on diagnosis, treatment history, insurance coverage, medical history, and individual clinical needs.

Learn more about SPRAVATO® treatment .

SPRAVATO® may be covered by commercial insurance, Medicare, Medicaid, or other health plans for patients who meet the medical and plan-specific eligibility requirements. Coverage varies by insurer, and prior authorization may be required.

NY Ketamine Infusions can help eligible patients understand coverage requirements before treatment. Learn more about SPRAVATO® insurance coverage .

NY Ketamine Infusions provides medically supervised SPRAVATO® treatment for eligible patients in New York City and Long Island. Patients are evaluated before treatment to determine whether SPRAVATO® is clinically appropriate and whether insurance authorization is required.

Patients seeking care on Long Island can learn more about SPRAVATO® treatment on Long Island , or visit our treatment locations to explore available care options.