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Get answers to common questions about ketamine therapy, treatment options, costs, SPRAVATO®, and choosing a provider in New York City and Long Island.
We provide ketamine infusion therapy for treatment-resistant depression, anxiety, PTSD, OCD, bipolar depression, and alcohol use disorder. Each patient undergoes a comprehensive evaluation to determine clinical appropriateness.
Ketamine blocks NMDA receptors, which leads to increased glutamate activity and stimulation of AMPA and mTOR pathways—fostering new synaptic connections. This neuroplastic effect helps restore balance in brain circuits involved in mood regulation.
Many patients report improvement within 2 to 4 hours of their first infusion. This rapid onset is a major advantage over traditional antidepressants, which can take weeks to work.
Relief typically lasts between one and two weeks after a single infusion. To sustain benefits, patients usually follow an initial series of six infusions over two to three weeks, with maintenance infusions as needed.
A standard protocol consists of six infusions over two to three weeks. Maintenance infusions are then scheduled every 3 to 6 weeks based on the patient’s symptom return and overall response.
During the infusion, patients may feel deeply relaxed or mildly dissociated. Some describe the experience as dream-like or “floating.” These effects are temporary and closely monitored by our team.
Mild dissociation is common and typically fades within an hour after the infusion. Our clinical staff monitors your experience throughout each session to ensure your comfort and safety.
Yes. Most patients benefit from ongoing maintenance infusions to preserve symptom relief. Frequency is individualized, typically every 3 to 6 weeks.
Yes. Ketamine can be an effective treatment for bipolar depression when carefully administered. We thoroughly assess all patients to ensure it’s appropriate for their diagnosis and history.
Ketamine therapy for mood disorders is not usually covered by insurance.
Ketamine has demonstrated rapid antidepressant effects in clinical research, particularly for people with treatment-resistant depression who have not improved adequately with conventional treatments. In a major randomized controlled trial, 64% of patients receiving IV ketamine met criteria for a clinical response 24 hours after treatment, compared with 28% receiving an active placebo. A large real-world systematic review involving more than 2,600 patients found an overall response rate of approximately 45% and a remission rate of approximately 30%, although individual outcomes varied considerably.
Evidence for anxiety is promising but less established. A systematic review and meta-analysis found that ketamine significantly reduced anxiety symptoms compared with placebo at less than 12 hours, at 24 hours, and at 7–14 days after treatment. However, many of the studies were relatively small, and researchers noted limitations in the quality of the available evidence.
IV ketamine treatment for depression and anxiety is considered an off-label use of ketamine. Treatment therefore requires an individualized medical evaluation to determine whether the potential benefits and risks are appropriate for a particular patient.
Rather than choosing a ketamine clinic based solely on advertising or proximity, patients should look for a medical practice that provides appropriate screening, physician oversight, monitoring during treatment, clear treatment protocols, and ongoing assessment of response.
Important factors to consider include:
NY Ketamine Infusions provides treatment for patients in the New York metropolitan area through locations serving New York City and Long Island. A consultation with a physician is used to determine whether ketamine or another treatment option may be appropriate.
The cost of IV ketamine treatment varies by provider, location, treatment protocol, and the number of infusions required.
At NY Ketamine Infusions, the currently published fee for a mental-health ketamine infusion is $525 per infusion. The total cost of treatment therefore depends on the number of initial treatments and any subsequent booster infusions recommended based on the patient's response.
IV ketamine used for mental-health conditions is generally not covered by insurance because its psychiatric use is off-label. NY Ketamine Infusions is an out-of-network provider and can provide claim documentation for patients who want to pursue possible reimbursement from their insurer. CareCredit financing is also available for eligible patients.
SPRAVATO® is different because it is an FDA-approved treatment for specific forms of depression. Insurance coverage may therefore be available depending on the patient's diagnosis, health plan, medical-necessity requirements, deductible, and prior-authorization requirements.
Yes. IV ketamine and SPRAVATO® (esketamine) are related treatments, but they are not the same medication, route of administration, regulatory indication, or treatment protocol.
IV ketamine contains racemic ketamine, which includes two molecular forms of ketamine. It is delivered directly into the bloodstream through an intravenous infusion. Although ketamine is FDA-approved as an anesthetic, using IV ketamine to treat depression or other psychiatric conditions is an off-label medical use.
SPRAVATO® contains esketamine, one component of the ketamine molecule, and is administered as a nasal spray. It is FDA-approved for treatment-resistant depression in adults and for depressive symptoms in adults with major depressive disorder and acute suicidal ideation or behavior under its approved indications.
SPRAVATO must be administered under healthcare supervision through the restricted SPRAVATO REMS program. Patients are monitored for at least two hours after administration because temporary sedation, dissociation, respiratory depression, and increases in blood pressure can occur.
The treatments also differ in insurance coverage. IV ketamine for psychiatric conditions is commonly self-pay, while SPRAVATO may be covered by insurance when a patient meets the insurer's eligibility and medical-necessity requirements.
Ratings can change over time, so patients should review current information from independent sources rather than relying exclusively on a clinic's own website.
When comparing ketamine infusion centers in New York City, Long Island, or another community, consider more than the star rating alone. Look at:
NY Ketamine Infusions currently serves patients through locations in New York City and Melville on Long Island. Patients should compare NY Ketamine Infusions with other qualified providers and choose a medical practice based on clinical experience, safety, treatment options, and their individual needs.
Patient reviews can be found through independent platforms such as Google Business Profiles and other established healthcare or local-review websites, as well as on individual clinic websites.
Independent reviews can be particularly helpful for understanding aspects of the patient experience such as communication with the medical team, comfort during treatment, office environment, scheduling, staff responsiveness, treatment experience, and follow-up care.
However, patient testimonials should not be interpreted as evidence that a treatment will produce the same result for everyone. Depression, anxiety, and other mood disorders vary considerably between individuals, and treatment response cannot be guaranteed.
The first consultation is designed to determine whether ketamine treatment is medically appropriate for you rather than automatically scheduling an infusion.
During a consultation, patients should generally be prepared to discuss:
The physician can then discuss whether IV ketamine, SPRAVATO®, another treatment, or continued care with the patient's existing mental-health providers may be appropriate.
Patients considering SPRAVATO may also need insurance-benefit verification and prior authorization before beginning treatment. Patients considering IV ketamine can discuss the expected treatment protocol, treatment costs, possible side effects, monitoring procedures, transportation requirements, and what to expect during and after an infusion.
The goal of the consultation is to create an individualized treatment plan based on clinical need rather than taking a one-size-fits-all approach.
Speak with the NY Ketamine Infusions team about IV ketamine, SPRAVATO®, treatment costs and whether an evaluation may be appropriate for you.
NY Ketamine Infusions provides advanced Ketamine therapy and SPRAVATO® treatment options for patients throughout New York City and Long Island. With locations serving Lower Manhattan and Melville, our team welcomes patients from nearby Manhattan, Brooklyn, western Suffolk County, eastern Nassau County, and surrounding communities. We help patients explore mental health services and treatment options for anxiety, depression, PTSD, OCD, Bipolar Disorder, Alcohol Dependence, and Treatment-resistant Depression (TRD) in a supportive clinical setting.
